RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy.

Authors :: Litosch I
Source :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2011 Nov 18; Vol. 415 (2), pp. 215-9. Date of Electronic Publication: 2011 Oct 18.
Publication Year :: 2011
Abstract: Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα(GTP) can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G(q) efficacy.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)