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[Structure, function and molecular design strategies of antibacterial peptide SMAP-29: a review].
- Source :
-
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2011 Jun; Vol. 27 (6), pp. 846-59. - Publication Year :
- 2011
-
Abstract
- Antibacterial peptides are a family of host-defense peptides most of which are gene-encoded and produced by living organisms of all types. Antibacterial peptides are small molecular proteins with broad antimicrobial spectrum against bacteria, viruses, fungi and sometimes even as anticancer peptide. SMAP-29, a cathelicidin-like peptide derived from sheep myeloid, line alpha-helical Structure, exerts a powerful broad antimicrobial activity against different pathogens including Gram-positive and Gram-negative bacteria, fungi, viruses, parasites, spirochaetes, chlamydia and antiendotoxin activity, and particular antibacterial mechanism, rapidly to permeabilize membranes of susceptible organisms. This paper summarizes the lately research progress of SMAP-29 and Variants including the characteristics of structure, structure-activity relationships, mode of action, diverse biological functions, gene recombinant and expression. We put emphasis on the necessity of molecular design, and primary and secondary structure-based modification, to provides a strong foundation for further drug development and design of SMAP-29.
- Subjects :
- Animals
Antimicrobial Cationic Peptides genetics
Antimicrobial Cationic Peptides physiology
Blood Proteins genetics
Blood Proteins physiology
Cathelicidins genetics
Cathelicidins physiology
Drug Design
Recombinant Proteins genetics
Sheep
Antimicrobial Cationic Peptides chemistry
Blood Proteins chemistry
Cathelicidins chemistry
Recombinant Proteins chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1000-3061
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Sheng wu gong cheng xue bao = Chinese journal of biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 22034813