Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation.

Authors :: Prüller F
Raggam RB
Posch V
Almer G
Truschnig-Wilders M
Horejsi R
Möller R
Weghuber D
Ille R
Schnedl W
Mangge H
Source :: Atherosclerosis [Atherosclerosis] 2012 Jan; Vol. 220 (1), pp. 215-8. Date of Electronic Publication: 2011 Oct 14.
Publication Year :: 2012
Abstract: Objective: Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism.<br />Methods: Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters.<br />Results: In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP.<br />Conclusion: Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

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