Back to Search
Start Over
Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2012 Aug; Vol. 25 (8), pp. 1338-41. Date of Electronic Publication: 2011 Nov 21. - Publication Year :
- 2012
-
Abstract
- Objective: The objective of the study is to investigate the association between oxidative stress markers and enzymatic / non-enzymatic antioxidants (marker of the resistance in body to oxidative damage) in the cord blood of preterm low birth weight (LBW) neonates.<br />Methods: Malondialdehyde (MDA), carbonyl proteins, total antioxidant capacity and Vitamin A, E and C levels in the cord blood were determined by spectrophotometry.<br />Results: Increased lipid peroxidation, protein oxidation with decreased values of vitamin A, E, C and total antioxidant capacity were observed in the preterm LBW newborns. Observations of negative correlation between MDA and protein carbonyl with antioxidants vitamin A, E and C and total antioxidant status points towards the existence of oxidative stress in the preterm LBW newborns.<br />Conclusions: Poor fetal growth affects the development of antioxidant defenses of preterm LBW babies, predisposing them to higher oxidative stress, which in turn may partly account for increased morbidity and mortality in these infants. The presence of an association between oxidative stress biomarkers and enzymatic /non-enzymatic antioxidants in the cord blood of preterm LBW neonates suggest that increased oxidative stress may be the result of changes in the levels of certain enzymatic and non-enzymatic antioxidants due to the cause or the effect of oxidative damage occurring at the molecular level.
- Subjects :
- Adult
Antioxidants analysis
Ascorbic Acid analysis
Ascorbic Acid blood
Ascorbic Acid metabolism
Biomarkers analysis
Biomarkers metabolism
Case-Control Studies
Female
Fetal Blood chemistry
Humans
Infant, Low Birth Weight metabolism
Infant, Newborn
Infant, Premature metabolism
Lipid Peroxidation physiology
Male
Malondialdehyde blood
Malondialdehyde metabolism
Pregnancy
Protein Carbonylation physiology
Vitamin A analysis
Vitamin A blood
Vitamin A metabolism
Vitamin E analysis
Vitamin E blood
Vitamin E metabolism
Young Adult
Antioxidants metabolism
Biomarkers blood
Fetal Blood metabolism
Infant, Low Birth Weight blood
Infant, Premature blood
Oxidative Stress physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4954
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 22046974
- Full Text :
- https://doi.org/10.3109/14767058.2011.633672