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Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2012 Mar; Vol. 14 (3), pp. 283-7. Date of Electronic Publication: 2011 Dec 02. - Publication Year :
- 2012
-
Abstract
- To compare the effects of miglitol [an alpha-glucosidase inhibitor (AGI) absorbed in the intestine] and voglibose (an AGI not absorbed) on plasma glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels, 26 and 24 Japanese type 2 diabetic patients were randomly assigned to receive miglitol or voglibose, respectively. After 12-week administration of both drugs, during 2-h meal tolerance test, plasma glucose, serum insulin and total GIP were significantly decreased and active GLP-1 was significantly increased. Miglitol group showed a significantly lower total GIP level than voglibose group. Miglitol, but not voglibose, significantly reduced body weight (BW). In all participants, the relative change in BW was positively correlated with that of insulin significantly and of GIP with a weak tendency, but not of GLP-1. In conclusion, both drugs can enhance postprandial GLP-1 responses and reduce GIP responses. The significant BW reduction by miglitol might be attributable to its strong GIP-reducing efficacy.<br /> (© 2011 Blackwell Publishing Ltd.)
- Subjects :
- 1-Deoxynojirimycin administration & dosage
1-Deoxynojirimycin pharmacology
Asian People
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 metabolism
Drug Administration Schedule
Female
Gastric Inhibitory Polypeptide drug effects
Glucagon-Like Peptide 1 drug effects
Humans
Hypoglycemic Agents administration & dosage
Inositol administration & dosage
Inositol pharmacology
Male
Middle Aged
Obesity blood
Obesity metabolism
Postprandial Period
1-Deoxynojirimycin analogs & derivatives
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemic Agents pharmacology
Incretins blood
Inositol analogs & derivatives
Obesity drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 22051162
- Full Text :
- https://doi.org/10.1111/j.1463-1326.2011.01526.x