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A newborn with overlapping features of AEC and EEC syndromes.
- Source :
-
American journal of medical genetics. Part A [Am J Med Genet A] 2011 Dec; Vol. 155A (12), pp. 3100-3. Date of Electronic Publication: 2011 Nov 07. - Publication Year :
- 2011
-
Abstract
- Ectrodactyly, ectodermal dysplasia, clefting (EEC) syndrome is the prototype of several p63 conditions, which include ankyloblepharon, ectodermal dysplasia, clefting (AEC) syndrome, limb-mammary syndrome (LMS), Rapp-Hodgkin syndrome (RHS), ADULT syndrome, and others. All these disorders include combinations of ectodermal dysplasia, orofacial clefting and limb malformations in variable severity. A newborn patient is presented with diffuse erythematous and desquamating skin lesions and anal atresia. She also had sparse and lightly colored thin hair, deeply set eyes, hypoplastic alae nasi, and a short philtrum. Cleft lip/palate and ankyloblepharon were not present. Complete cutaneous syndactyly was present on both hands in between the third and fourth fingers. Mild ectrodactyly was evident on all four extremities in between first and second digits. There was post-axial polydactyly on both feet. Anal atresia was present and defecation occurred through a rectovaginal fistula. The patient represented an interesting overlapping clinical condition between AEC and EEC syndromes. Diffuse skin lesions with excoriation and desquamation suggest AEC syndrome, despite the absence of ankyloblepharon, however; ectrodactyly and polydactyly strongly suggest the EEC syndrome. C308Y mutation in exon 8 of TP63 gene was detected, which was previously described to lead only to EEC syndrome and not to any of the other allelic conditions. These data emphasize the large degree of clinical variability that may be seen for specific TP63 mutations.<br /> (Copyright © 2011 Wiley Periodicals, Inc.)
- Subjects :
- Amino Acid Substitution
Cleft Lip genetics
Cleft Palate genetics
Ectodermal Dysplasia genetics
Eye Abnormalities genetics
Eyelids abnormalities
Fatal Outcome
Female
Humans
Infant, Newborn
Mutation
Transcription Factors genetics
Tumor Suppressor Proteins genetics
Cleft Lip diagnosis
Cleft Palate diagnosis
Ectodermal Dysplasia diagnosis
Eye Abnormalities diagnosis
Phenotype
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4833
- Volume :
- 155A
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 22065614
- Full Text :
- https://doi.org/10.1002/ajmg.a.34328