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Multi-locus analysis reveals a different pattern of genetic diversity for mitochondrial and nuclear DNA between wild and domestic pigs in East Asia.
- Source :
-
PloS one [PLoS One] 2011; Vol. 6 (10), pp. e26416. Date of Electronic Publication: 2011 Oct 31. - Publication Year :
- 2011
-
Abstract
- Background: A major reduction of genetic diversity in mtDNA occurred during the domestication of East Asian pigs. However, the extent to which genetic diversity has been lost in the nuclear genome is uncertain. To reveal levels and patterns of nucleotide diversity and to elucidate the genetic relationships and demographic history of domestic pigs and their ancestors, wild boars, we investigated 14 nuclear markers (including 8 functional genes, 2 pseudogenes and 4 intergenic regions) from 11 different chromosomes in East Asia-wide samples and pooled them with previously obtained mtDNA data for a combined analysis.<br />Principal Findings: The results indicated that domestic pigs and wild boars possess comparable levels of nucleotide diversity across the nuclear genome, which is inconsistent with patterns that have been found in mitochondrial genome.<br />Conclusions: This incongruence between the mtDNA and nuclear genomes is suggestive of a large-scale backcross between male wild boars and female domestic pigs in East Asia. Our data reveal the impacts of founder effects and backcross on the pig genome and help us better understand the complex demographic histories of East Asian pigs, which will be useful for future work on artificial selection.
- Subjects :
- Animals
Bayes Theorem
Cluster Analysis
Crosses, Genetic
Asia, Eastern
Female
Founder Effect
Genes, Mitochondrial genetics
Genetic Markers
Genetics, Population
Geography
Linkage Disequilibrium genetics
Male
Models, Genetic
Molecular Sequence Data
Open Reading Frames genetics
Population Dynamics
Recombination, Genetic genetics
Cell Nucleus genetics
DNA, Mitochondrial genetics
Genetic Loci genetics
Genetic Variation
Sus scrofa genetics
Swine genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 6
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 22065995
- Full Text :
- https://doi.org/10.1371/journal.pone.0026416