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Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2012 Apr; Vol. 220 (4), pp. 647-72. Date of Electronic Publication: 2011 Nov 10. - Publication Year :
- 2012
-
Abstract
- Rationale: Spontaneous (novel) object recognition (SOR) is one of the most widely used rodent behavioural tests. The opportunity for rapid data collection has made SOR a popular choice in studies that explore cognitive impairment in rodent models of schizophrenia, and that test the efficacy of drugs intended to reverse these deficits.<br />Objectives: We provide an overview of the many recent studies that have used SOR to explore the mnemonic effects of manipulation of the key transmitter systems relevant to schizophrenia-the dopamine, glutamate, GABA, acetylcholine, serotonin and cannabinoid systems-alone or in combination. We also review the use of SOR in studying memory in genetically modified mouse models of schizophrenia, as well as in neurodevelopmental and lesion models. We end by discussing the construct and predictive validity, and translational relevance, of SOR with respect to cognitive impairment in schizophrenia.<br />Results: Perturbation of the dopamine or glutamate systems can generate robust and reliable impairment in SOR. Impaired performance is also seen following antagonism of the muscarinic acetylcholine system, or exposure to cannabinoid agonists. Cognitive enhancement has been reported using alpha7-nicotinic acetylcholine receptor agonists and 5-HT(6) antagonists. Among non-pharmacological models, neonatal ventral hippocampal lesions and maternal immune activation can impair SOR, while mixed results have been obtained with mice carrying mutations in schizophrenia risk-associated genes, including neuregulin and COMT.<br />Conclusions: While SOR is not without its limitations, the task represents a useful method for studying manipulations with relevance to cognitive impairment in schizophrenia, as well as the interactions between them.
- Subjects :
- Animals
Cognition Disorders drug therapy
Cognition Disorders genetics
Cognition Disorders pathology
Humans
Mice
Rats
Recognition, Psychology drug effects
Rodentia
Schizophrenia pathology
Species Specificity
Time Factors
Antipsychotic Agents therapeutic use
Disease Models, Animal
Recognition, Psychology physiology
Schizophrenia drug therapy
Schizophrenia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 220
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22068459
- Full Text :
- https://doi.org/10.1007/s00213-011-2536-5