Back to Search
Start Over
Shiga toxin interaction with human intestinal epithelium.
- Source :
-
Toxins [Toxins (Basel)] 2011 Jun; Vol. 3 (6), pp. 626-39. Date of Electronic Publication: 2011 Jun 14. - Publication Year :
- 2011
-
Abstract
- After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has been described so far, and it is assumed that Stx are released into the gut lumen after bacterial lysis. Human intestinal epithelium does not express the Stx receptor Gb3 or other Stx binding sites, and it remains unknown how Stx cross the intestinal epithelial barrier and gain access to the systemic circulation. This review summarises current knowledge about the influence of the intestinal environment on Stx production and release, Stx interaction with intestinal epithelial cells and intracellular uptake, and toxin translocation into underlying tissues. Furthermore, it highlights gaps in understanding that need to be addressed by future research.
- Subjects :
- Animals
Bacterial Outer Membrane Proteins metabolism
Bacteriophages
Binding Sites
Humans
Intestinal Mucosa drug effects
Protein Transport
Shiga Toxin 1 genetics
Shiga Toxin 1 metabolism
Shiga Toxin 2 genetics
Shiga Toxin 2 metabolism
Trihexosylceramides genetics
Enterohemorrhagic Escherichia coli pathogenicity
Enterohemorrhagic Escherichia coli virology
Escherichia coli Infections microbiology
Host-Pathogen Interactions
Intestinal Mucosa microbiology
Shiga Toxin 1 toxicity
Shiga Toxin 2 toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 3
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 22069729
- Full Text :
- https://doi.org/10.3390/toxins3060626