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[Synchronous double cancer of the gallbladder and rectum successfully treated with S-1 as second-line chemotherapy- a case report].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2011 Nov; Vol. 38 (11), pp. 1857-9. - Publication Year :
- 2011
-
Abstract
- A 66-year-old man was referred to our hospital with obstructive jaundice. Computed tomography(CT)scan showed thickening of the gallbladder wall, invasion into the liver bed, and thickening of the rectal wall. Colonoscopy revealed a type 2 rectal cancer, in which adenocarcinoma was identified by endoscopic biopsy. He was diagnosed with double-cancer of the gallbladder and rectum. Because his gallbladder cancer was more life threatening than his rectal cancer, gemcitabine was administered at 1, 000 mg/m2 on days 1, 8, and 15 of a 28-day course. After 3 courses of gemcitabine, the CT scan showed that the lymph nodes in the hepatoduodenal ligament had been enlarged, and duodenal stenosis had occurred as a result of gallbladder cancer invasion. S-1 was administered orally at doses of 120 mg/day twice daily on days 1-28 of a 42-day course. Partial response was confirmed by CT scan. After 8 courses of S-1, the gallbladder cancer had progressed and liver metastases had appeared. He subsequently died of disease progression. He survived for 17 months after the first course of chemotherapy, and the progression-free survival with S-1 was 10 months. Therefore, S-1 could be an effective agent for synchronous double cancer of the gallbladder and rectum.
- Subjects :
- Aged
Combined Modality Therapy
Drug Combinations
Fatal Outcome
Gallbladder Neoplasms pathology
Gallbladder Neoplasms surgery
Humans
Male
Neoplasms, Multiple Primary pathology
Neoplasms, Multiple Primary surgery
Rectal Neoplasms pathology
Rectal Neoplasms surgery
Tomography, X-Ray Computed
Antimetabolites, Antineoplastic therapeutic use
Gallbladder Neoplasms drug therapy
Neoplasms, Multiple Primary drug therapy
Oxonic Acid therapeutic use
Rectal Neoplasms drug therapy
Salvage Therapy
Tegafur therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 38
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22083197