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Effect of mannitol on cerebral blood volume in patients with head injury.
- Source :
-
Neurosurgery [Neurosurgery] 2012 May; Vol. 70 (5), pp. 1215-8; discussion 1219. - Publication Year :
- 2012
-
Abstract
- Background: Mannitol has traditionally been the mainstay of medical therapy for intracranial hypertension in patients with head injury. We previously demonstrated that mannitol reduces brain volume in patients with cerebral edema, although whether this occurs because of a reduction in brain water, blood volume, or both remains poorly understood.<br />Objective: To test the hypothesis that mannitol acts by lowering blood viscosity leading to reflex vasoconstriction and a fall in cerebral blood volume (CBV).<br />Methods: We used O positron emission tomography to study 6 patients with traumatic brain injuries requiring treatment for intracranial hypertension. Cerebral blood flow (CBF), CBV, and cerebral metabolic rate for oxygen (CMRO2) were measured before and 1 hour after administration of 1.0 g/kg 20% mannitol.<br />Results: CBV rose from 4.1 ± 0.4 to 4.2 ± 0.2 mL/100 g (P = .3), while intracranial pressure fell from 21.5 ± 4.9 to 13.7 ± 5.1 mm Hg (P < .003) after mannitol. Blood pressure, PaCO2, oxygen content, CBF, and CMRO2 did not change.<br />Conclusion: A single bolus of 1 g/kg of 20% mannitol does not acutely lower CBV. Another mechanism, such as a reduction in brain water, may better explain mannitol's ability to lower intracranial pressure and reduce mass effect.
- Subjects :
- Adult
Blood Viscosity drug effects
Craniocerebral Trauma complications
Diuretics, Osmotic administration & dosage
Humans
Intracranial Hypertension etiology
Male
Treatment Outcome
Vasoconstriction drug effects
Blood Volume drug effects
Craniocerebral Trauma drug therapy
Craniocerebral Trauma physiopathology
Intracranial Hypertension drug therapy
Intracranial Hypertension physiopathology
Mannitol administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4040
- Volume :
- 70
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 22089753
- Full Text :
- https://doi.org/10.1227/NEU.0b013e3182417bc2