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Analysis of a genome-wide association study-linked locus (CCR6) in Asian rheumatoid arthritis.
- Source :
-
DNA and cell biology [DNA Cell Biol] 2012 Apr; Vol. 31 (4), pp. 607-10. Date of Electronic Publication: 2011 Nov 17. - Publication Year :
- 2012
-
Abstract
- A genome-wide association study in Japan identified the C-C chemokine receptor type 6 gene (CCR6) as associated with rheumatoid arthritis (RA). This finding has not been validated in other Asian populations. A case-control study involving 996 subjects, comprising 440 controls and 556 RA patients, was done to determine their anticyclic citrullinated peptide (anti-CCP) antibody status and CCR6 polymorphism (rs3093024) genotype. Three hundred eighty-seven patients were anti-CCP positive and 153 anti-CCP negative. Logistic regression showed that allele A was likely to increase the risk of developing RA among females via a recessive model (odds ratio [OR]=1.55, 95% confidence interval [CI]=1.01, 2.39), whereas the risk effect appeared to be reduced among males via an additive model (OR=0.60, 95% CI=0.42, 0.85). Considering only subjects who are anti-CCP positive, allele A increased RA risk among females via a recessive model (OR=1.68, 95% CI=1.07, 2.64) but decreased the risk among males via an additive model (OR=0.59, 95% CI=0.39, 0.89). We showed that CCR6 polymorphism was a risk factor among females but a protective factor among males. Functional studies are warranted to unravel the pathophysiological relevance of the gene variant and other linked variants with RA.
- Subjects :
- Arthritis, Rheumatoid epidemiology
Case-Control Studies
Female
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Japan epidemiology
Logistic Models
Male
Models, Genetic
Odds Ratio
Risk Factors
Sex Factors
Arthritis, Rheumatoid genetics
Asian People genetics
Genetic Predisposition to Disease genetics
Receptors, CCR6 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7430
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- DNA and cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 22092173
- Full Text :
- https://doi.org/10.1089/dna.2011.1350