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Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis.
- Source :
-
Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2012 Feb; Vol. 241 (2), pp. 229-41. Date of Electronic Publication: 2011 Nov 18. - Publication Year :
- 2012
-
Abstract
- Background: The neural crest (NC) and placode are transient neurogenic cell populations that give rise to cranial ganglia of the vertebrate head. The formation of the anterior NC- and placode-derived ganglia has been shown to depend on the single activity of either Neurog1 or Neurog2. The requirement of the more posterior cranial ganglia on Neurog1 and Neurog2 is unknown.<br />Results: Here we show that the formation of the NC-derived parasympathetic otic ganglia and placode-derived visceral sensory petrosal and nodose ganglia are dependent on the redundant activities of Neurog1 and Neurog2. Tamoxifen-inducible Cre lineage labeling of Neurog1 and Neurog2 show a dynamic spatiotemporal expression profile in both NC and epibranchial placode that correlates with the phenotypes of the Neurog-mutant embryos.<br />Conclusion: Our data, together with previous studies, suggest that the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both NC and epibranchial placode.<br /> (Copyright © 2011 Wiley-Liss, Inc.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Ganglia, Parasympathetic metabolism
Mice
Mice, Mutant Strains
Nerve Tissue Proteins genetics
Neural Crest metabolism
Basic Helix-Loop-Helix Transcription Factors metabolism
Ear embryology
Ear innervation
Ganglia, Parasympathetic embryology
Nerve Tissue Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0177
- Volume :
- 241
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental dynamics : an official publication of the American Association of Anatomists
- Publication Type :
- Academic Journal
- Accession number :
- 22102600
- Full Text :
- https://doi.org/10.1002/dvdy.22785