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Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis.

Authors :
Takano-Maruyama M
Chen Y
Gaufo GO
Source :
Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2012 Feb; Vol. 241 (2), pp. 229-41. Date of Electronic Publication: 2011 Nov 18.
Publication Year :
2012

Abstract

Background: The neural crest (NC) and placode are transient neurogenic cell populations that give rise to cranial ganglia of the vertebrate head. The formation of the anterior NC- and placode-derived ganglia has been shown to depend on the single activity of either Neurog1 or Neurog2. The requirement of the more posterior cranial ganglia on Neurog1 and Neurog2 is unknown.<br />Results: Here we show that the formation of the NC-derived parasympathetic otic ganglia and placode-derived visceral sensory petrosal and nodose ganglia are dependent on the redundant activities of Neurog1 and Neurog2. Tamoxifen-inducible Cre lineage labeling of Neurog1 and Neurog2 show a dynamic spatiotemporal expression profile in both NC and epibranchial placode that correlates with the phenotypes of the Neurog-mutant embryos.<br />Conclusion: Our data, together with previous studies, suggest that the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both NC and epibranchial placode.<br /> (Copyright © 2011 Wiley-Liss, Inc.)

Details

Language :
English
ISSN :
1097-0177
Volume :
241
Issue :
2
Database :
MEDLINE
Journal :
Developmental dynamics : an official publication of the American Association of Anatomists
Publication Type :
Academic Journal
Accession number :
22102600
Full Text :
https://doi.org/10.1002/dvdy.22785