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EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma.

Authors :
Li Z
Chen X
Li L
Liu S
Yang L
Ma X
Tang M
Bode AM
Dong Z
Sun L
Cao Y
Source :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2012 Feb; Vol. 44 (2), pp. 275-9. Date of Electronic Publication: 2011 Nov 17.
Publication Year :
2012

Abstract

miRNAs (microRNAs) are a class of non-coding small RNAs. The Epstein-Barr-virus (EBV) encoded miR-BHRF1-1 is barely expressed in most nasopharyngeal carcinoma (NPC) cells with EBV latent infection. Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle. The data further suggested that the miR-BHRF1-1-potentiated induction of EBV lytic replication was accompanied by inhibiting p53 expression. Our results demonstrated that the EBV original pathogen miR-BHRF1-1 is involved in the control of EBV late lytic replication by directly targeting the host p53 gene.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1878-5875
Volume :
44
Issue :
2
Database :
MEDLINE
Journal :
The international journal of biochemistry & cell biology
Publication Type :
Academic Journal
Accession number :
22108199
Full Text :
https://doi.org/10.1016/j.biocel.2011.11.007