Back to Search
Start Over
Drug release from electric-field-responsive nanoparticles.
- Source :
-
ACS nano [ACS Nano] 2012 Jan 24; Vol. 6 (1), pp. 227-33. Date of Electronic Publication: 2011 Nov 30. - Publication Year :
- 2012
-
Abstract
- We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.<br /> (© 2011 American Chemical Society)
- Subjects :
- Diffusion
Electromagnetic Fields
Materials Testing
Pharmaceutical Preparations radiation effects
Delayed-Action Preparations chemistry
Delayed-Action Preparations radiation effects
Nanocapsules chemistry
Nanocapsules radiation effects
Pharmaceutical Preparations chemistry
Polymers chemistry
Polymers radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 22111891
- Full Text :
- https://doi.org/10.1021/nn203430m