Immunogenicity of delayed TBE-vaccine booster.

Authors :: Askling HH
Vene S
Rombo L
Lindquist L
Source :: Vaccine [Vaccine] 2012 Jan 11; Vol. 30 (3), pp. 499-502. Date of Electronic Publication: 2011 Nov 26.
Publication Year :: 2012
Abstract: Information is scarce regarding the antibody response when TBE-vaccine booster doses are delayed, which is a common situation in daily life. We have investigated the immune response after a delayed booster dose compared to a normal booster interval in an every-day setting. Overall, 250/260 (96%) of the study participants had neutralizing antibodies post-booster, with no significant difference between normal and delayed booster intervals. Based on our findings we propose that healthy individuals who have failed adherence to the recommended schedule of TBE-vaccination can be given a delayed dose without concern of immunogenicity.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)