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Ferulic acid is nephrodamaging while gallic acid is renal protective in long term treatment of chronic kidney disease.
- Source :
-
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2012 Jun; Vol. 31 (3), pp. 405-14. Date of Electronic Publication: 2011 Dec 10. - Publication Year :
- 2012
-
Abstract
- Backgrounds & Aims: The long term therapeutic effect of ferulic acid (FA) and gallic acid (GA) in treatment of chronic kidney disease (CKD) has been lacking.<br />Methods: Doxorubicin (DR, Adriamycin)-induced CKD rat model was established for this study.<br />Results: DR significantly reduced levels of serum albumin, GOT, GPT, RBC, TNF-α, and urinary creatinine and elevated serum cholesterol, TG, BUN, creatinine, uric acid, WBC, platelet count, and IL-6. In DRCKD rats, FA and GA significantly increased kidney weight and glomerular volume. FA reduced glomerular filtration rate but GA did not. FA enhanced more collagen deposition than GA in renal cortex and glomeruli. Both FA and GA showed crucial hyperlipidemic activity. The inhibitory effects of FA and GA on MMP-2 were very comparable. GA suppressed MMP-2 more effectively than FA in DRCKD rats. Both FA and GA induced SOD elevation and MDA elimination. In DRCKD rats, Western blot analysis indicated that FA further up-regulated CD34, α-SMA, tissue pDGFR, p-PDGFR, and TGF-β; and down-regulated p-PI3K, and p-Akt. Since both PDGF-BB and TGF-β are considered to induce kidney prefibrosis stage, GA was proved to be more beneficial in this regard.<br />Conclusions: GA tends to protect the CKD while FA is not recommended for the long term CKD therapy.<br /> (Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
- Subjects :
- Animals
Antioxidants therapeutic use
Collagen metabolism
Coumaric Acids therapeutic use
Disease Models, Animal
Fibrosis
Gallic Acid therapeutic use
Gene Expression Regulation
Glomerular Filtration Rate
Hyperlipidemias etiology
Hyperlipidemias prevention & control
Kidney metabolism
Kidney physiopathology
Male
Organ Size
RNA, Messenger metabolism
Rats
Rats, Sprague-Dawley
Renal Insufficiency, Chronic metabolism
Renal Insufficiency, Chronic pathology
Renal Insufficiency, Chronic physiopathology
Signal Transduction
Toxicity Tests, Chronic
Antioxidants adverse effects
Coumaric Acids adverse effects
Dietary Supplements adverse effects
Gallic Acid adverse effects
Kidney pathology
Renal Insufficiency, Chronic diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 22154988
- Full Text :
- https://doi.org/10.1016/j.clnu.2011.11.003