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Immunomodulatory activity of polysaccharide-protein complex of longan (Dimocarpus longan Lour.) pulp.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2011 Dec 13; Vol. 16 (12), pp. 10324-36. Date of Electronic Publication: 2011 Dec 13. - Publication Year :
- 2011
-
Abstract
- The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg⁻¹d⁻¹ LP3 (P < 0.05). The beneficial effects of 50-200 mgkg⁻¹d⁻¹ LP3 were comparable to those of 50 mgkg⁻¹d⁻¹ ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
- Subjects :
- Animals
Body Weight drug effects
Cell Death drug effects
Cell Proliferation drug effects
Chickens
Drinking Behavior drug effects
Feeding Behavior drug effects
Hemolysin Proteins blood
Interferon-gamma blood
Interleukin-2 blood
Killer Cells, Natural cytology
Killer Cells, Natural drug effects
Lymphocytes cytology
Lymphocytes drug effects
Macrophages cytology
Macrophages drug effects
Male
Mice
Phagocytosis drug effects
Spleen cytology
Spleen drug effects
Thymus Gland drug effects
Glycoproteins chemistry
Glycoproteins pharmacology
Immunologic Factors pharmacology
Plant Extracts pharmacology
Polysaccharides pharmacology
Sapindaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 22158685
- Full Text :
- https://doi.org/10.3390/molecules161210324