Back to Search
Start Over
Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline.
- Source :
-
Journal of genetic counseling [J Genet Couns] 2012 Aug; Vol. 21 (4), pp. 484-93. Date of Electronic Publication: 2011 Dec 14. - Publication Year :
- 2012
-
Abstract
- Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterologists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.
- Subjects :
- Adaptor Proteins, Signal Transducing genetics
Adenosine Triphosphatases genetics
Antigens, Neoplasm genetics
Base Pair Mismatch
Cell Adhesion Molecules genetics
Colorectal Neoplasms, Hereditary Nonpolyposis pathology
DNA Methylation
DNA Repair
DNA Repair Enzymes genetics
DNA-Binding Proteins genetics
Epithelial Cell Adhesion Molecule
Humans
Immunohistochemistry
Microsatellite Instability
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
Nuclear Proteins genetics
Proto-Oncogene Proteins B-raf genetics
Colorectal Neoplasms genetics
Colorectal Neoplasms, Hereditary Nonpolyposis genetics
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing
Societies, Medical
Subjects
Details
- Language :
- English
- ISSN :
- 1573-3599
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of genetic counseling
- Publication Type :
- Academic Journal
- Accession number :
- 22167527
- Full Text :
- https://doi.org/10.1007/s10897-011-9465-7