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Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 15; Vol. 22 (2), pp. 1068-72. Date of Electronic Publication: 2011 Dec 06. - Publication Year :
- 2012
-
Abstract
- Facile synthesis of two new series of tetracyclic azepine and oxazocine analogs is described. These analogs were evaluated for their potential as MAPKAP-K2 (MK2) inhibitors and several were found to be potent at inhibiting MK2 with a non-ATP competitive binding mode.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Azepines chemical synthesis
Azepines chemistry
Humans
Molecular Structure
Oxazocines chemical synthesis
Oxazocines chemistry
Protein Kinase Inhibitors chemical synthesis
Protein Kinase Inhibitors chemistry
Stereoisomerism
Structure-Activity Relationship
Azepines pharmacology
Intracellular Signaling Peptides and Proteins antagonists & inhibitors
Oxazocines pharmacology
Protein Kinase Inhibitors pharmacology
Protein Serine-Threonine Kinases antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 22182499
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.11.113