Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction.

Authors :: Lattanzi A
De Fusco C
Russo A
Poater A
Cavallo L
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 Feb 04; Vol. 48 (11), pp. 1650-2. Date of Electronic Publication: 2011 Dec 21.
Publication Year :: 2012
Abstract: A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C(6)F(6).<br /> (This journal is © The Royal Society of Chemistry 2012)

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