Back to Search
Start Over
Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
- Source :
-
Phytochemistry [Phytochemistry] 2012 Mar; Vol. 75, pp. 99-107. Date of Electronic Publication: 2011 Dec 21. - Publication Year :
- 2012
-
Abstract
- Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in 13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC₅₀ below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC₅₀ 0.17 nM and SI 187,010.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents isolation & purification
Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Cell Line, Tumor
Cell Proliferation drug effects
Diterpenes chemistry
Diterpenes isolation & purification
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Esters chemistry
Esters isolation & purification
HL-60 Cells
Humans
Molecular Conformation
Plant Extracts chemistry
Plant Extracts isolation & purification
Stereoisomerism
Structure-Activity Relationship
Anti-HIV Agents pharmacology
Antineoplastic Agents pharmacology
Daphne chemistry
Diterpenes pharmacology
Esters pharmacology
HIV-1 drug effects
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 75
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22196934
- Full Text :
- https://doi.org/10.1016/j.phytochem.2011.11.013