Back to Search
Start Over
Lifestyle and the risk of dementia in Japanese-american men.
- Source :
-
Journal of the American Geriatrics Society [J Am Geriatr Soc] 2012 Jan; Vol. 60 (1), pp. 118-23. Date of Electronic Publication: 2011 Dec 28. - Publication Year :
- 2012
-
Abstract
- Objectives: To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia.<br />Design: Case-control study nested in a prospective cohort.<br />Setting: The Honolulu-Asia Aging Study, Oahu, Hawaii.<br />Participants: Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965-1968) examined for dementia 25 years later.<br />Measurements: Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m(2) , physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for developing overall dementia, Alzheimer's disease (AD), and vascular dementia (VaD), adjusting for potential confounders.<br />Results: Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia (OR = 1.87, 95% CI = 1.26-2.77; BMI > 25.0 vs <22.6 kg/m(2) ). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia (OR = 0.36, 95% CI = 0.15-0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone.<br />Conclusion: Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life.<br /> (© 2011, Copyright the Authors Journal compilation © 2011, The American Geriatrics Society.)
Details
- Language :
- English
- ISSN :
- 1532-5415
- Volume :
- 60
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 22211390
- Full Text :
- https://doi.org/10.1111/j.1532-5415.2011.03768.x