Back to Search
Start Over
An egg-enriched diet attenuates plasma lipids and mediates cholesterol metabolism of high-cholesterol fed rats.
- Source :
-
Lipids [Lipids] 2012 Mar; Vol. 47 (3), pp. 269-77. Date of Electronic Publication: 2012 Jan 11. - Publication Year :
- 2012
-
Abstract
- We investigated the influence of an egg-enriched diet on plasma, hepatic and fecal lipid levels and on gene expression levels of transporters, receptors and enzymes involved in cholesterol metabolism. Sprague-Dawley rats fed an egg-enriched diet had lower plasma triglycerides, total cholesterol, low density lipoprotein (LDL)-cholesterol, hepatic triglyceride, and cholesterol concentrations, and greater plasma high-density lipoprotein cholesterol concentration, fecal neutral sterol and bile acid concentrations than those fed a plain cholesterol diet. Chicken egg yolk had no effect on sterol 12α-hydroxylase and sterol 27α-hydroxylase; but upregulated mRNA levels of hepatic LDL-receptor, cholesterol 7α-hydroxylase (CYP7A1) and lecithin cholesterol acyltransferase, and downregulated hepatic hydroxymethylglutaryl-(HMG)-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) after 90 days. Modification of the lipoprotein profile by an egg-enriched diet was mediated by reducing de novo cholesterol synthesis and enhancing the excretion of fecal cholesterol, via upregulation of CYP7A1 and the LDL receptor, and downregulation of HMG-CoA reductase and ACAT.
- Subjects :
- Animals
Cholesterol 7-alpha-Hydroxylase genetics
Cholesterol 7-alpha-Hydroxylase metabolism
Diet
Lipids blood
Liver enzymology
Liver metabolism
Male
Rats
Rats, Sprague-Dawley
Receptors, LDL genetics
Receptors, LDL metabolism
Sterol O-Acyltransferase genetics
Sterol O-Acyltransferase metabolism
Triglycerides metabolism
Cholesterol metabolism
Eggs
Subjects
Details
- Language :
- English
- ISSN :
- 1558-9307
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Lipids
- Publication Type :
- Academic Journal
- Accession number :
- 22234516
- Full Text :
- https://doi.org/10.1007/s11745-011-3646-x