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Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2012 Jan 14; Vol. 12, pp. 6. Date of Electronic Publication: 2012 Jan 14. - Publication Year :
- 2012
-
Abstract
- Background: Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine challenge.<br />Methods: We recruited healthy PM+ and PM- infants at birth. At six and 12 months, we stimulated PBMCs with tuberculin purified protein derivative (PPD) and compared expression of CD154, IL-2 and IFNγ by CD4 T-cells to a negative control using flow cytometry.We measured the length, weight and head circumference at birth and 12 months.<br />Results: IL-2 and CD154 expression were low in both groups at both timepoints, without discernable differences. Expression of IFNγ was similarly low at 6 months but by 12 months, the median response was higher in PM- than PM + infants (p = 0.026). The PM+ infants also had a lower weight (p = 0.032) and head circumference (p = 0.041) at 12 months, indicating lower growth rates.At birth, the size and weight of the PM+ and PM- infants were equivalent. By 12 months, the PM+ infants had a lower weight and head circumference than the PM- infants.<br />Conclusions: Placental malaria was associated with reduced immune responses 12 months after immune challenge in infants apparently healthy at birth.
- Subjects :
- CD40 Ligand biosynthesis
Cells, Cultured
Female
Flow Cytometry
Humans
Infant
Infant, Newborn
Interferon-gamma biosynthesis
Interleukin-2 biosynthesis
Leukocytes, Mononuclear immunology
Pregnancy
Tuberculin Test
CD4-Positive T-Lymphocytes immunology
Malaria complications
Malaria immunology
Placenta Diseases immunology
Tuberculin immunology
Tuberculosis Vaccines administration & dosage
Tuberculosis Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22243970
- Full Text :
- https://doi.org/10.1186/1471-2334-12-6