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Listeria monocytogenes and its products as agents for cancer immunotherapy.
- Source :
-
Advances in immunology [Adv Immunol] 2012; Vol. 113, pp. 81-118. - Publication Year :
- 2012
-
Abstract
- This review covers the use of Listeria monocytogenes and its virulence factors as cancer immunotherapeutics. We describe their development as vectors to carry protein tumor antigen and eukaryotic DNA plasmids to antigen-presenting cells and efforts to harness their tumor-homing properties. We also describe their use as vectors of angiogenic molecules to induce an immune response that will destroy tumor vasculature. The background knowledge necessary to understand the biology behind the rationale to develop Listeria as a vaccine vector for tumor immunotherapy is included as well as a brief summary of the major therapies that have used this approach thus far.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antigen-Presenting Cells immunology
Antigen-Presenting Cells microbiology
Antigens, Neoplasm genetics
Antigens, Neoplasm immunology
Antigens, Neoplasm metabolism
Cancer Vaccines therapeutic use
Humans
Listeria monocytogenes pathogenicity
Neovascularization, Pathologic prevention & control
Virulence Factors genetics
Cancer Vaccines immunology
Immunotherapy methods
Listeria monocytogenes immunology
Neoplasms therapy
Virulence Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8445
- Volume :
- 113
- Database :
- MEDLINE
- Journal :
- Advances in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22244580
- Full Text :
- https://doi.org/10.1016/B978-0-12-394590-7.00004-X