Back to Search
Start Over
Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic target.
- Source :
-
Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2012 Aug; Vol. 13 (10), pp. 1861-7. - Publication Year :
- 2012
-
Abstract
- Psoriasis is a common (1-3% of the population worldwide), multifactorial, immune-mediated chronic skin disease. In psoriasis pathogenesis an over-reaction of local innate immune response initiates inflammation with subsequent involvement of adaptive immune response leading to the production of a panel of cytokines, chemokines and growth factors leading to epidermal hyperplasia. Recently, IL-21 has been involved in this process as this cytokine is overexpressed in psoriatic skin and can cause epidermal hyperplasia and inflammation when injected intradermally into mice. Moreover blockade of IL-21 with a human antibody against IL-21 reduces the epidermal thickness and the expression of Th1 and Th17 genes in the well-characterized model of human psoriasis-xenograft mouse. Therefore, the inhibition of this cytokine may be therapeutically effective in the treatment of psoriasis. Here we will review recent data on psoriasis pathogenesis focusing on the role of IL-21 as novel therapeutic target.
- Subjects :
- Animals
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents adverse effects
Anti-Inflammatory Agents therapeutic use
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal adverse effects
Antibodies, Monoclonal therapeutic use
Dendritic Cells drug effects
Dendritic Cells immunology
Humans
Immunity, Innate genetics
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents adverse effects
Immunosuppressive Agents therapeutic use
Interleukins genetics
Interleukins immunology
Keratinocytes drug effects
Keratinocytes immunology
Psoriasis genetics
Psoriasis immunology
T-Lymphocytes drug effects
T-Lymphocytes immunology
Interleukins antagonists & inhibitors
Psoriasis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4316
- Volume :
- 13
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Current pharmaceutical biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 22250707
- Full Text :
- https://doi.org/10.2174/138920112802273281