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Neurodevelopmental follow-up at five years corrected age of extremely low birth weight infants after postnatal replacement of 17β-estradiol and progesterone.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2012 Mar; Vol. 97 (3), pp. 1041-7. Date of Electronic Publication: 2012 Jan 18. - Publication Year :
- 2012
-
Abstract
- Context: Extremely low birth weight (ELBW) infants are prone to impaired neurodevelopment.<br />Objective: The aim was to determine long-term neurodevelopmental outcome in ELBW infants after postnatal 17β-estradiol (E2) and progesterone (P) replacement.<br />Design: At 5-yr corrected age, ELBW infants were assessed for standardized cognitive and neurological outcome after postnatal randomized E2 and P replacement or placebo administration.<br />Setting: The follow-up examination was performed in a neuropediatric ambulatory care center.<br />Patients: Sixty-one of 71 surviving infants (86%) were available for follow-up.<br />Main Outcome Measures: Cognitive and neurological outcome was evaluated using the Kaufmann Assessment Battery for Children, the Gross Motor Function Classification Scale, and clinical neurological examination.<br />Results: No significant differences were found between the replacement and placebo groups for the Gross Motor Function Classification Scale, presence of paresis, cerebral palsy, spasticity, and ametropia. However, a significant time-response relationship was found with E2 and P replacement. Every day of treatment reduced the risk for cerebral palsy (P=0.03), spasticity (P=0.01), and ametropia (P=0.01).<br />Conclusion: Postnatal E2 and P replacement may have potential in improving neurodevelopmental outcome in ELBW infants. Larger trials are needed to test this new hypothesis.
- Subjects :
- Child Development drug effects
Child, Preschool
Double-Blind Method
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Treatment Outcome
Child Development physiology
Estradiol therapeutic use
Hormone Replacement Therapy methods
Infant, Extremely Low Birth Weight growth & development
Progesterone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 97
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 22259065
- Full Text :
- https://doi.org/10.1210/jc.2011-2612