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Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2012 Apr 01; Vol. 185 (7), pp. 723-30. Date of Electronic Publication: 2012 Jan 26. - Publication Year :
- 2012
-
Abstract
- Rationale: IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract.<br />Objectives: To evaluate the relationship between IgE antibodies to α-gal and asthma, and compare this with the relationship between asthma and IgE antibodies to Fel d 1 and other protein allergens.<br />Methods: Patients being investigated for recurrent anaphylaxis, angioedema, or acute urticaria underwent spirometry, exhaled nitric oxide, questionnaires, and serum IgE antibody assays. The results were compared with control subjects and cohorts from the emergency department in Virginia (n = 130), northern Sweden (n = 963), and rural Kenya (n = 131).<br />Measurements and Main Results: Patients in Virginia with high-titer IgE antibodies to α-gal had normal lung function, low levels of exhaled nitric oxide, and low prevalence of asthma symptoms. Among patients in the emergency department and children in Kenya, there was no association between IgE antibodies to α-gal and asthma (odds ratios, 1.04 and 0.75, respectively). In Sweden, IgE antibodies to cat were closely correlated with IgE antibodies to Fel d 1 (r = 0.83) and to asthma (P < 0.001).<br />Conclusions: These results provide a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and further evidence that the main allergens that are causally related to asthma are those that are inhaled.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anaphylaxis etiology
Animals
Asthma etiology
Case-Control Studies
Child
Emergency Service, Hospital statistics & numerical data
Female
Humans
Male
Middle Aged
Nitric Oxide metabolism
Norway
Risk Factors
Spirometry
Sweden
Ticks immunology
Virginia
Young Adult
Anaphylaxis immunology
Asthma immunology
Disaccharides immunology
Immunoglobulin E immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1535-4970
- Volume :
- 185
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22281828
- Full Text :
- https://doi.org/10.1164/rccm.201111-2017OC