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Short-term versus long-term administration of single prophylactic antibiotic in elective gastric tumor surgery.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2012 Sep; Vol. 59 (118), pp. 1784-8. - Publication Year :
- 2012
-
Abstract
- Background/aims: To evaluate short-term versus long-term single prophylactic antibiotic for elective gastric tumor surgery.<br />Methodology: Patients in a single surgical team undergoing elective gastric tumor surgery were enrolled from November 2009 to December 2010. The included patients were aged from 18 to 70 years without conditions as severe comorbidity, preoperative infectious diseases, antibiotic administration 48 h before surgery, exploratory laparotomy only or combined colorectal resection, neoadjuvant chemotherapy, or steroid administration before surgery. The overall and infection-related postoperative complications and also economic outcomes were analyzed. The software SPSS 17.0 and TreeAge Pro 2007 were used for statistics.<br />Results: Patients (n=158 (45 vs. 113)) were enrolled in short-term and long-term groups. No death cases occurred. Overall postoperative complication rates were 8.9% and 8.0%, respectively (p=1.000). The rates of infection related complications were 8.9% and 4.4%, respectively (p=0.231). No surgical site infection (SSI) occurred in the short-term group, whereas SSI was 1.8% in the long-term group. Total hospitalization cost (THC) of short-term branch was 36,557RMB per patients and preferable against 39,523RMB of long-term branch. Incremental cost-effectiveness analysis showed there was a 10 times interval between the extra healthcare expenditure of benefit and harm.<br />Conclusions: Short-term administration did not increase the risk of postoperative complications and was more cost-effective.
- Subjects :
- Adolescent
Adult
Aged
Analysis of Variance
Anti-Bacterial Agents economics
Bacterial Infections microbiology
Chi-Square Distribution
China
Cost-Benefit Analysis
Drug Administration Schedule
Drug Costs
Elective Surgical Procedures
Female
Hospital Costs
Humans
Male
Middle Aged
Models, Economic
Retrospective Studies
Risk Assessment
Risk Factors
Stomach Neoplasms economics
Surgical Wound Infection economics
Surgical Wound Infection microbiology
Time Factors
Treatment Outcome
Young Adult
Anti-Bacterial Agents administration & dosage
Antibiotic Prophylaxis economics
Bacterial Infections prevention & control
Gastrectomy adverse effects
Gastrectomy economics
Gastric Bypass adverse effects
Gastric Bypass economics
Stomach Neoplasms surgery
Surgical Wound Infection prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 59
- Issue :
- 118
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 22282038
- Full Text :
- https://doi.org/10.5754/hge11784