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Low-dose docetaxel combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts.
- Source :
-
Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2012 Apr; Vol. 27 (3), pp. 204-9. Date of Electronic Publication: 2012 Jan 27. - Publication Year :
- 2012
-
Abstract
- Low-dose metronomic (LDM) chemotherapy represents a new strategy to treat solid tumors by stronger antiangiogenic activity and less side-effects, especially in combination with other antiangiogenic agents. The aim of the study is to investigate the antiangiogenic effect of docetaxel alone and combined with (-)-epigallocatechin-3-gallate (EGCG) in preclinical settings of gastric cancer. BGC-823 human gastric cancer xenograft model was used, and tumor growth, side-effects of mice were closely monitored. Expression of vascular endothelial growth factor and CD31 were observed by immunohistochemistry, and microvessel density of the tumor tissues was assessed by CD31 immunohistochemical analysis. Our results indicated that LDM docetaxel inhibited angiogenesis and growth of gastric cancer with less toxicity, and the effects were further enhanced by the concurrent administration of EGCG. Our study, for the first time, rationally demonstrated that LDM docetaxel treatment used alone or combined with EGCG is effective and safe in preclinical settings of gastric cancer. Our data suggest that LDM docetaxel used alone or combined with EGCG may be an innovative and promising therapeutic strategy in the experimental treatment of human gastric cancer.
- Subjects :
- Animals
Catechin administration & dosage
Catechin analogs & derivatives
Docetaxel
Dose-Response Relationship, Drug
Drug Synergism
Humans
Immunoenzyme Techniques
Mice
Mice, Inbred BALB C
Mice, Nude
Microvessels drug effects
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Stomach Neoplasms pathology
Taxoids administration & dosage
Tumor Cells, Cultured
Vascular Endothelial Growth Factor A metabolism
Xenograft Model Antitumor Assays
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Apoptosis drug effects
Cell Proliferation drug effects
Neovascularization, Pathologic prevention & control
Stomach Neoplasms blood supply
Stomach Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8852
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer biotherapy & radiopharmaceuticals
- Publication Type :
- Academic Journal
- Accession number :
- 22283637
- Full Text :
- https://doi.org/10.1089/cbr.2011.1103