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Pathological and immunohistochemical studies of subclinical infection of chicken anemia virus in 4-week-old chickens.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2012 Jun; Vol. 74 (6), pp. 757-64. Date of Electronic Publication: 2012 Jan 30. - Publication Year :
- 2012
-
Abstract
- Subclinical infection of chicken anemia virus (CAV) at 4 to 6 weeks of age, after maternal antibodies have waned, is implicated in several field problems in broiler flocks. In order to understand the pathogenesis of subclinical infection with CAV, an immunopathological study of CAV-inoculated 4-week-old SPF chickens was performed. Sixty 4-week-old SPF chickens were equally divided into CAV and control groups. The CAV group was inoculated intramuscularly with the MSB1-TK5803 strain of CAV. Neither mortality nor anemia was detected in the CAV and control groups. In the CAV group, no signs were observed, except that some chickens were grossly smaller compared with the control group. Sporadic thymus lobes appeared to be reddening and atrophied. Within the first two weeks p.i. of CAV, there was a mild to moderate depletion of lymphocytes in the thymus cortex and spleen in some chickens. Moreover, lymphoid depletion of the bursa of Fabricius, proventriculus and cecal tonsils was observed. Hyperplastic lymphoid foci were observed in the liver, lungs, kidneys and heart at the 4th week p.i. of CAV. Immunohistochemically, a moderate lymphoid depletion of CD4(+)and CD8(+) T cells in the thymus cortex and spleen was observed in some chickens within two weeks p.i. of CAV. CAV inclusions and antigens were detected infrequently in the thymus cortex and spleen. It could be concluded that the immunosuppression in subclinical infection with CAV occurs as a result of reduction of cellular immunity.
- Subjects :
- Animals
Bursa of Fabricius immunology
Case-Control Studies
Circoviridae Infections immunology
Circoviridae Infections pathology
Immunohistochemistry veterinary
Lymphocyte Count veterinary
Poultry Diseases immunology
Specific Pathogen-Free Organisms
Spleen immunology
Thymus Gland immunology
Thymus Gland pathology
Chicken anemia virus immunology
Chickens
Circoviridae Infections veterinary
Immunity, Cellular immunology
Poultry Diseases pathology
Poultry Diseases virology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 74
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 22293470
- Full Text :
- https://doi.org/10.1292/jvms.11-0374