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Models of aspects of schizophrenia: behavioral sensitization induced by subchronic phencyclidine administration.
- Source :
-
Current protocols in pharmacology [Curr Protoc Pharmacol] 2009 Jun; Vol. Chapter 5, pp. Unit 5.54. - Publication Year :
- 2009
-
Abstract
- Presented in this unit is a protocol using subchronically administered phencyclidine (PCP) for establishing a behavioral sensitization model of aspects of schizophrenia. This model is validated using haloperidol and risperidone. The end-point of the assay is locomotor hyperactivity, which is induced by PCP challenge following subchronic treatment with this NMDA receptor antagonist. The antipsychotics haloperidol, risperidone, and quetiapine all reduce hyperactivity in a dose-dependent and selective manner. While the effects of other antipsychotics such as clozapine, olanzapine, and ziprasidone are similar to haloperidol, the interpretation of responses to them is often confounded by nonspecific effects during habituation.<br /> (© 2009 by John Wiley & Sons, Inc.)
- Subjects :
- Animals
Antipsychotic Agents administration & dosage
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical methods
Hyperkinesis prevention & control
Male
Rats
Rats, Sprague-Dawley
Schizophrenia chemically induced
Antipsychotic Agents pharmacology
Hallucinogens administration & dosage
Hyperkinesis chemically induced
Phencyclidine administration & dosage
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1934-8290
- Volume :
- Chapter 5
- Database :
- MEDLINE
- Journal :
- Current protocols in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22294400
- Full Text :
- https://doi.org/10.1002/0471141755.ph0554s45