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[Effect of Pulsatilla Decoction on the expression of proinflammatory cytokines in inflammatory bowel disease].
- Source :
-
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2011 Nov; Vol. 27 (4), pp. 416-9. - Publication Year :
- 2011
-
Abstract
- Objective: To investigate the molecular mechanisms underlying in the treatment of inflammatory bowel disease by Pulsatilla Decoction.<br />Methods: Forty Wistar male rats were randomly divided into 5 groups( n = 8)control group, model group, model + positive control group (mesalazine), Pulsatilla Decoction treatment group, in addition, the Pulsatilla Decoction treatment group was divided into middle and high dose group. Intragastric administration was used in the positive control group and Pulsatilla Decoction treatment group. The expression of interleukin-1beta (IL-1beta), interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) were detected by real time PCR after extraction of RNA from colons.<br />Results: Compared with the model group, positive medicine and Pulsatilla Decoction group, especially high-dose group, could effectively inhibit the expression of IL-1beta, IL-6 and TNF-alpha.<br />Conclusion: Pulsatilla Decoction could exert its effect in the treatment of inflammatory bowel disease by inhibiting the expression of proinflammatory cytokines.
- Subjects :
- Animals
Drugs, Chinese Herbal therapeutic use
Inflammatory Bowel Diseases metabolism
Interleukin-1beta genetics
Interleukin-6 genetics
Male
Phytotherapy
RNA, Messenger genetics
RNA, Messenger metabolism
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha genetics
Drugs, Chinese Herbal pharmacology
Inflammatory Bowel Diseases drug therapy
Interleukin-1beta metabolism
Interleukin-6 metabolism
Pulsatilla chemistry
Tumor Necrosis Factor-alpha metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1000-6834
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
- Publication Type :
- Academic Journal
- Accession number :
- 22295514