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Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles.
- Source :
-
Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2012 May; Vol. 28 (5), pp. 561-72. Date of Electronic Publication: 2012 Feb 02. - Publication Year :
- 2012
-
Abstract
- Objectives: Calcium and phosphate ion-releasing resin composites are promising for remineralization. However, there has been no report on incorporating antibacterial agents to these composites. The objective of this study was to develop antibacterial and mechanically strong nanocomposites incorporating a quaternary ammonium dimethacrylate (QADM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP).<br />Methods: The QADM, bis(2-methacryloyloxyethyl) dimethylammonium bromide (ionic dimethacrylate-1), was synthesized from 2-(N,N-dimethylamino)ethyl methacrylate and 2-bromoethyl methacrylate. NAg was synthesized by dissolving Ag 2-ethylhexanoate salt in 2-(tert-butylamino)ethyl methacrylate. Mechanical properties were measured in three-point flexure with bars of 2 mm×2 mm×25 mm (n=6). Composite disks (diameter=9 mm, thickness=2 mm) were inoculated with Streptococcus mutans. The metabolic activity and lactic acid production of biofilms were measured (n=6). Two commercial composites were used as controls.<br />Results: Flexural strength and elastic modulus of NACP+QADM, NACP+NAg, and NACP+QADM+NAg matched those of commercial composites with no antibacterial property (p>0.1). The NACP+QADM+NAg composite decreased the titer counts of adherent S. mutans biofilms by an order of magnitude, compared to the commercial composites (p<0.05). The metabolic activity and lactic acid production of biofilms on NACP+QADM+NAg composite were much less than those on commercial composites (p<0.05). Combining QADM and NAg rendered the nanocomposite more strongly antibacterial than either agent alone (p<0.05).<br />Significance: QADM and NAg were incorporated into calcium phosphate composite for the first time. NACP+QADM+NAg was strongly antibacterial and greatly reduced the titer counts, metabolic activity, and acid production of S. mutans biofilms, while possessing mechanical properties similar to commercial composites. These nanocomposites are promising to have the double benefits of remineralization and antibacterial capabilities to inhibit dental caries.<br /> (Copyright © 2012 Academy of Dental Materials. All rights reserved.)
- Subjects :
- Acrylic Resins chemistry
Anti-Bacterial Agents chemistry
Bacterial Adhesion drug effects
Bacterial Load drug effects
Biofilms drug effects
Bisphenol A-Glycidyl Methacrylate chemistry
Calcium Phosphates chemistry
Composite Resins chemistry
Dental Materials chemistry
Elastic Modulus
Fluorides chemistry
Fluorides pharmacology
Glass chemistry
Humans
Lactic Acid analysis
Materials Testing
Methacrylates chemistry
Methacrylates pharmacology
Microbial Viability drug effects
Microscopy, Electron, Transmission
Nanoparticles chemistry
Pliability
Polyethylene Glycols chemistry
Polymethacrylic Acids chemistry
Polyurethanes chemistry
Quaternary Ammonium Compounds chemistry
Silver chemistry
Streptococcus mutans drug effects
Anti-Bacterial Agents pharmacology
Calcium Phosphates pharmacology
Composite Resins pharmacology
Dental Materials pharmacology
Nanocomposites chemistry
Quaternary Ammonium Compounds pharmacology
Silver pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0097
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Dental materials : official publication of the Academy of Dental Materials
- Publication Type :
- Academic Journal
- Accession number :
- 22305716
- Full Text :
- https://doi.org/10.1016/j.dental.2012.01.005