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Prevalence of human papillomavirus and Epstein-Barr virus DNA in penile cancer cases from Brazil.
- Source :
-
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2012 Feb; Vol. 107 (1), pp. 18-23. - Publication Year :
- 2012
-
Abstract
- Penile cancer is a potentially mutilating disease. Although its occurrence is relatively rare worldwide, penile cancer rates can be high in developing countries. A few studies have been conducted on the involvement of human papillomavirus (HPV) in penile carcinoma, which have found HPV present in 30-70% of penile malignant lesions, with a higher prevalence of HPV 16 and 18. It has been assumed that cofactors, such as Epstein-Barr virus (EBV) infections, may play a role in the progression of penile neoplasia. The aim of this study was to determine HPV and EBV prevalence in 135 penile malignant lesions from Brazilian men through the use of MY09/11 polymerase chain reaction (PCR), type-specific PCR and restriction fragment length polymorphism analysis. HPV prevalence among the men tested was 60.7%. Of the men who tested positive, 27 presented with HPV 16 (29.7%), five with HPV 18 (5.5%), 21 with HPV 45 (23.1%) and nine with HPV 6 (9.9%). Seven mixed infections were detected (9.2%), while 11 cases remained untyped (13.4%). Regarding EBV positivity, 46.7% of the samples contained EBV DNA with EBV-1 as the most prevalent type (74.6%). More than 23% of the men were co-infected with both HPV and EBV, while 35% presented exclusively with HPV DNA and 20% presented only with EBV DNA. Penile carcinoma aetiology has not been fully elucidated and the role of HPV and EBV infections individually or synergistically is still controversial. Hence, more studies are needed to determine their possible role in carcinogenesis.
- Subjects :
- Adult
Aged
Aged, 80 and over
Brazil epidemiology
Carcinoma in Situ epidemiology
Carcinoma in Situ virology
Carcinoma, Squamous Cell epidemiology
Cross-Sectional Studies
DNA, Viral analysis
DNA, Viral genetics
Epstein-Barr Virus Infections diagnosis
Epstein-Barr Virus Infections epidemiology
Genotype
Herpesvirus 4, Human genetics
Humans
Male
Middle Aged
Papillomaviridae genetics
Papillomavirus Infections diagnosis
Papillomavirus Infections epidemiology
Penile Neoplasms epidemiology
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prevalence
Tumor Virus Infections diagnosis
Tumor Virus Infections epidemiology
Tumor Virus Infections virology
Young Adult
Carcinoma, Squamous Cell virology
Herpesvirus 4, Human isolation & purification
Papillomaviridae isolation & purification
Penile Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1678-8060
- Volume :
- 107
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- 22310531
- Full Text :
- https://doi.org/10.1590/s0074-02762012000100003