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Outcomes of pediatric ABO-incompatible kidney transplantations are equivalent to ABO-compatible controls.
- Source :
-
Transplantation proceedings [Transplant Proc] 2012 Jan; Vol. 44 (1), pp. 214-6. - Publication Year :
- 2012
-
Abstract
- Background: Due to the profound shortage of suitable deceased allografts, much effort has been made to investigate whether successful kidney transplantation (KT) is possible across the ABO blood group barrier even for pediatric recipients.<br />Methods: We reviewed 52 consecutive ABO incompatible (ABOic) transplantation performed between September 1989 and March 2011. The mean age at transplantation was 10.6 ± 3.9 years (range, 4.4-19.7), with 35 boys and 17 girls. The donor-to-recipient ABO blood antigen incompatibility was as follows: A1/O (n = 17); B/O (n = 13); A1/B (n = 6); B/A1 (n = 1); A1B/B (n = 9); and A1B/A (n = 6). As a control group, data were collected from 271 pediatric ABO compatible (ABOc) living donor KT in the same period.<br />Results: Overall acute rejection episodes (ARE) among the ABOic group were significantly higher than those of the ABOc group (44% vs 26%; P < .02). However, there was no difference in glomerular filtration rate (GFR) at 1 year after transplantation: 86 ± 31 mL/min for ABOic vs 99 ± 37 mL/min for ABOic, respectively. The 1-y, 5-y, and 10-year patient survival rates were 98%, 92%, and 92% in the ABOic group, respectively, and 99%, 98%, and 97% in the ABOc group, respectively (P = not significant [NS]). The overall 1-, 5-, 10-, and 15-year graft survival rates were 94%, 88%, 86%, and 86% in the ABOic group, respectively, and 95%, 92%, 88%, and 78% in the ABOc group, respectively.<br />Conclusion: ABOic KT provided long-term allograft and patient survivals equivalent to ABOc live donor transplantations.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Age Factors
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Cytomegalovirus Infections virology
Desensitization, Immunologic adverse effects
Drug Therapy, Combination
Female
Glomerular Filtration Rate
Graft Rejection immunology
Graft Rejection prevention & control
Graft Survival
Humans
Immunosuppressive Agents adverse effects
Kidney Transplantation adverse effects
Living Donors
Male
Plasmapheresis adverse effects
Risk Assessment
Risk Factors
Splenectomy adverse effects
Time Factors
Treatment Outcome
Young Adult
ABO Blood-Group System immunology
Blood Group Incompatibility immunology
Histocompatibility
Kidney Failure, Chronic surgery
Kidney Transplantation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 22310617
- Full Text :
- https://doi.org/10.1016/j.transproceed.2011.12.017