Apolar carbohydrates as DNA capping agents.

Authors :: Lucas R
Vengut-Climent E
Gómez-Pinto I
Aviñó A
Eritja R
González C
Morales JC
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 Mar 21; Vol. 48 (24), pp. 2991-3. Date of Electronic Publication: 2012 Feb 07.
Publication Year :: 2012
Abstract: Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C-G base pairs. Here we present an apolar version of glucose and cellobiose as new capping agents that stack on DNA increasing considerably its stability with respect to their natural polyhydroxylated mono- and disaccharide DNA conjugates.