Back to Search
Start Over
Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration.
- Source :
-
Thrombosis and haemostasis [Thromb Haemost] 2012 Apr; Vol. 107 (4), pp. 656-61. Date of Electronic Publication: 2012 Feb 08. - Publication Year :
- 2012
-
Abstract
- The liver possesses impressive regenerative capacities. Grafts of embryonic liver explants and liver explant-conditioned media have been shown to enhance the mitotic activity of hepatocytes. Hepatocyte growth factor (HGF), also named scatter factor (SF), has been identified as a primary candidate in promoting and regulating liver regeneration. Although initially thought to be a liver-specific mitogen, HGF was later reported to have mitogenic, motogenic, morphogenic, and anti-apoptotic activities in various cell types. By promoting angiogenesis and inhibiting apoptosis, endogenous HGF may play an important role in cardioprotection as well as in the regeneration of endothelial cells and cardiomyocytes after myocardial infarction. Since serum concentration of HGF increases in the early phase of myocardial infarction and in heart failure, HGF may also play a key role as a prognostic and diagnostic biomarker of cardiovascular disease. Here we discuss the role of HGF as a biomarker and mediator in cardioprotection and cardiovascular regeneration.
- Subjects :
- Adult Stem Cells cytology
Animals
Apoptosis
Endothelial Cells cytology
Gene Expression Regulation
Heart Failure
Humans
Mice
Models, Biological
Myocardial Infarction metabolism
Neovascularization, Physiologic
Rats
Biomarkers metabolism
Cardiovascular Diseases metabolism
Cardiovascular System metabolism
Hepatocyte Growth Factor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2567-689X
- Volume :
- 107
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Thrombosis and haemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 22318499
- Full Text :
- https://doi.org/10.1160/TH11-10-0711