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Treatment of hepatitis C recurrence is less successful in female than in male liver transplant recipients.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2012 Apr; Vol. 25 (4), pp. 448-54. Date of Electronic Publication: 2012 Feb 21. - Publication Year :
- 2012
-
Abstract
- It has been recently suggested that the risk of graft loss after liver transplantation (LT) may increase in female HCV patients. The aim of the study was to examine gender differences in HCV therapy tolerance and outcome in LT patients treated for HCV recurrence. A retrospective study was conducted on liver recipients with HCV recurrence, who were given antiviral therapy from 2001 to 2009 in 12 transplant centers in Italy. Sustained virological response (SVR), adherence-to-therapy, and side effects were evaluated. A multivariate logistic regression model was used after adjusting for possible confounders. The data regarding 342 treated patients were analyzed. SVR was reported in 38.8% of patients. At baseline, male and female did not differ in HCV viral load, histology, or rate of diabetes. SVR was lower in females than in males (29.5% vs. 42.1%; P=0.03). Adherence-to-therapy was also lower in females than in males 43.4% vs. 23.8%; P=0.001); anemia was the main reason for lower adherence. In a multivariate analysis in patients Genotype1, female gender (P<0.04), early virological response (P<0.0001), and adherence to therapy (P<0.0001) were independent predictors for SVR. In conclusion, female gender represents an independent negative prognostic factor for the outcome of HCV antiviral therapy after LT.<br /> (© 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.)
- Subjects :
- Adult
Aged
Female
Hepacivirus genetics
Humans
Male
Middle Aged
Patient Compliance
RNA, Viral blood
Recurrence
Retrospective Studies
Sex Factors
Treatment Outcome
Viral Load
Antiviral Agents therapeutic use
Hepatitis C, Chronic virology
Interferon-alpha therapeutic use
Liver Transplantation
Polyethylene Glycols therapeutic use
Ribavirin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 22353419
- Full Text :
- https://doi.org/10.1111/j.1432-2277.2012.01440.x