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Effects of Nigella sativa and albendazole alone and in combination in Toxocara canis infected mice.
- Source :
-
JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2011 Sep; Vol. 61 (9), pp. 866-70. - Publication Year :
- 2011
-
Abstract
- Objective: Nigella sativa extract has been used in the Middle East as a traditional medicine for several complaints. We aimed to evaluate the biochemical, histopathological and hematologic changes in Toxocara canis-infected mice after treatment with Nigella sativa extract, albendazole or a combination of both.<br />Methods: This comparative study was conducted between June and July 2008 at the Itarran University Saniturla Turkey. Sixty healthy adult BALB/c male mice were randomly divided into six groups (D0-D5). Mice in groups D1-D5 received 500 embryonated T. canis eggs via esophageal tube. Groups DO and D1 served as a non-infected sham group and an infected control group, respectively. Groups D2 and D3 received 100 and 200 mg/kg N. sativa extract (NSE), respectively. Group D4 received 100 mg/kg albendazole. Group D5 received the combination dose (100+100 mg/kg NSE+albendazole).<br />Results: Treatment with N. sativa of both doses or the combination dose of N. sativa and albendazole reduced the degree of inflammation and necrosis, lead to a reduction in the percentage of eosinophils and decreased the elevated liver enzyme levels.<br />Conclusion: These results indicate that N. sativa has a potent effect in protection against organ damage induced by T. canis infection.
- Subjects :
- Albendazole pharmacology
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical methods
Drug Therapy, Combination
Male
Mice
Mice, Inbred BALB C
Random Allocation
Treatment Outcome
Albendazole therapeutic use
Anthelmintics therapeutic use
Nigella sativa
Phytotherapy
Plant Extracts therapeutic use
Toxocara canis
Toxocariasis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0030-9982
- Volume :
- 61
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- JPMA. The Journal of the Pakistan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 22360025