Impact of the CATIE trial on antipsychotic prescribing patterns at a state psychiatric facility.

Authors :: Koranek AM
Smith TL
Mican LM
Rascati KL
Source :: Schizophrenia research [Schizophr Res] 2012 May; Vol. 137 (1-3), pp. 137-40. Date of Electronic Publication: 2012 Feb 23.
Publication Year :: 2012
Abstract: Introduction: Results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) indicate that, with the exception of olanzapine, no substantial overall differences were identified between second generation antipsychotics (SGAs) and the first generation antipsychotic (FGA) perphenazine.<br />Methods: This study evaluated the effect of CATIE on antipsychotic prescribing. A retrospective review of 1807 adults with schizophrenia was conducted and relative quarterly percentages of FGA versus SGA prescriptions were calculated.<br />Results: Time series analysis did not identify significant differences in rates of FGA prescriptions.<br />Conclusions: Critiques of the methods used in CATIE may have mitigated its potential impact on antipsychotic prescribing despite cost-effectiveness of perphenazine treatment.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)

Subjects :: Adult
Age Factors
Aged
Benzodiazepines therapeutic use
Female
Hospitals, State statistics & numerical data
Humans
Male
Middle Aged
Olanzapine
Perphenazine therapeutic use
Retrospective Studies
Sex Factors
Time Factors
Antipsychotic Agents therapeutic use
Drug Prescriptions statistics & numerical data
Hospitals, Psychiatric statistics & numerical data
Schizophrenia drug therapy

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