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A gene-brain-cognition pathway: prefrontal activity mediates the effect of COMT on cognitive control and IQ.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2013 Mar; Vol. 23 (3), pp. 552-9. Date of Electronic Publication: 2012 Feb 24. - Publication Year :
- 2013
-
Abstract
- A core thesis of cognitive neurogenetic research is that genetic effects on cognitive ability are mediated by specific neural functions, however, demonstrating neural mediation has proved elusive. Pairwise relationships between genetic variation and brain function have yielded heterogeneous findings to date. This heterogeneity indicates that a multiple mediator modeling approach may be useful to account for complex relationships involving function at multiple brain regions. This is relevant not only for characterizing healthy cognition but for modeling the complex neural pathways by which disease-related genetic effects are transmitted to disordered cognitive phenotypes in psychiatric illness. Here, in 160 genotyped functional magnetic resonance imaging participants, we used a multiple mediator model to test a gene-brain-cognition pathway by which activity in 4 prefrontal brain regions mediates the effects of catechol-O-methyltransferase (COMT) gene on cognitive control and IQ. Results provide evidence for gene-brain-cognition mediation and help delineate a pathway by which gene expression contributes to intelligence.
- Subjects :
- Brain Mapping
Female
Genotype
Humans
Intelligence Tests
Magnetic Resonance Imaging
Male
Models, Neurological
Phenotype
Polymorphism, Single Nucleotide
Reverse Transcriptase Polymerase Chain Reaction
Young Adult
Catechol O-Methyltransferase genetics
Cognition physiology
Intelligence genetics
Prefrontal Cortex physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 22368081
- Full Text :
- https://doi.org/10.1093/cercor/bhs035