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Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 2012 Oct; Vol. 56 (4), pp. 1567-74. Date of Electronic Publication: 2012 Sep 11. - Publication Year :
- 2012
-
Abstract
- Sustained hepatic inflammation, driven by alcohol consumption, nonalcoholic fatty liver disease, and/or chronic viral hepatitis (hepatitis B and C), results in damage to parenchyma, oxidative stress, and compensatory regeneration/proliferation. There is substantial evidence linking these inflammation-associated events with the increased incidence of hepatocellular carcinogenesis. Although acute liver inflammation can play a vital and beneficial role in response to liver damage or acute infection, the effects of chronic liver inflammation, including liver fibrosis and cirrhosis, are sufficient in a fraction of individuals to initiate the process of transformation and the development of hepatocellular carcinoma. This review highlights immune-dependent mechanisms that may be associated with hepatocellular oncogenesis, including critical transformative events/pathways in the context of chronic inflammation and subverted tolerogenesis.<br /> (Copyright © 2012 American Association for the Study of Liver Diseases.)
- Subjects :
- Carcinoma, Hepatocellular immunology
Cell Transformation, Neoplastic pathology
Fatty Liver immunology
Fatty Liver pathology
Hepatitis B, Chronic immunology
Hepatitis B, Chronic pathology
Hepatitis C, Chronic immunology
Hepatitis C, Chronic pathology
Hepatitis, Chronic immunology
Hepatitis, Chronic pathology
Hepatitis, Viral, Human immunology
Humans
Liver Cirrhosis immunology
Liver Cirrhosis pathology
Liver Neoplasms immunology
Non-alcoholic Fatty Liver Disease
Oxidative Stress immunology
Oxidative Stress physiology
Precancerous Conditions pathology
Prognosis
Carcinoma, Hepatocellular pathology
Cell Transformation, Neoplastic immunology
Hepatitis, Viral, Human pathology
Liver Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3350
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 22378061
- Full Text :
- https://doi.org/10.1002/hep.25674