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Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2012 Jun; Vol. 29 (6), pp. 974-82. Date of Electronic Publication: 2012 Feb 28. - Publication Year :
- 2012
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Abstract
- Thalassemia and sickle-cell anemia (SCA) present a major public health problem in countries where the number of carriers and affected individuals is high. As a result of the abnormalities in hemoglobin production, cells of thalassemia and SCA patients exhibit oxidative stress, which ultimately is responsible for the chronic anemia observed. Therefore, identification of compounds exhibiting both antioxidant and hemoglobin-inducing activities is highly needed. Our results demonstrate resveratrol to be such a compound. This was shown both in the human K562 cell line, as well as in erythroid precursors derived from normal donors and β-thalassemia patients. Resveratrol was shown to exhibit antioxidant activity and to stimulate the expression of the γ-globin genes and the accumulation of fetal hemoglobin (HbF). To the best of our knowledge, this is the first report pointing to such a double effect of resveratrol. Since this natural product is already marketed as an antioxidant, future investigations should concentrate on demonstrating its potential to augment HbF production in experimental animal models (e.g., thalassemia and SCA mice) as well as in patients. We believe that the potential of clinical use of resveratrol as an antioxidant and HbF stimulator may offer a simple and inexpensive treatment to patients.
- Subjects :
- Antioxidants chemistry
Cell Differentiation drug effects
Cell Proliferation drug effects
Erythroid Cells drug effects
Erythroid Precursor Cells drug effects
Erythroid Precursor Cells metabolism
Erythroid Precursor Cells pathology
Fetal Hemoglobin metabolism
Gene Expression Regulation drug effects
Humans
K562 Cells
Oxidation-Reduction drug effects
Promoter Regions, Genetic genetics
Protein Biosynthesis drug effects
Proteomics
RNA, Messenger genetics
RNA, Messenger metabolism
Reactive Oxygen Species metabolism
Resveratrol
Stilbenes chemistry
Transcription, Genetic drug effects
beta-Globins genetics
gamma-Globins genetics
Antioxidants pharmacology
Erythroid Cells metabolism
Erythroid Cells pathology
Fetal Hemoglobin genetics
Stilbenes pharmacology
Tissue Donors
beta-Thalassemia pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-244X
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22378234
- Full Text :
- https://doi.org/10.3892/ijmm.2012.928