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Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials.
- Source :
-
The American journal of clinical nutrition [Am J Clin Nutr] 2012 Apr; Vol. 95 (4), pp. 972-80. Date of Electronic Publication: 2012 Feb 29. - Publication Year :
- 2012
-
Abstract
- Background: Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies.<br />Objective: The objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules.<br />Design: We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews.<br />Results: Eighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: I² = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: I² = 26%, P = 0.26).<br />Conclusions: n-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis.
- Subjects :
- Adult
Aged
Atherosclerosis etiology
Atherosclerosis prevention & control
Biomarkers blood
Dyslipidemias blood
Dyslipidemias immunology
E-Selectin blood
Female
Humans
Intercellular Adhesion Molecule-1 chemistry
Male
P-Selectin blood
Randomized Controlled Trials as Topic
Solubility
Vascular Cell Adhesion Molecule-1 blood
Vascular Cell Adhesion Molecule-1 chemistry
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Dietary Supplements
Dyslipidemias diet therapy
Fatty Acids, Omega-3 therapeutic use
Intercellular Adhesion Molecule-1 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3207
- Volume :
- 95
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22378734
- Full Text :
- https://doi.org/10.3945/ajcn.111.025924