Synthesis of simplified tedanolide analogues--connecting tedanolide to myriaporone and gephyronic acid.

Authors :: Diaz N
Naini A
Muthukumar Y
Sasse F
Kalesse M
Source :: ChemMedChem [ChemMedChem] 2012 May; Vol. 7 (5), pp. 771-5. Date of Electronic Publication: 2012 Mar 01.
Publication Year :: 2012
Abstract: Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and evaluated for potency in mammalian cancer cells. The truncated analogues were found to retain significant activity in vitro (23 μmol mL(-1) for the example shown) compared with the parent compound tedanolide (0.33 nmol mL(-1)), and represent potential leads for the development of novel anticancer agents.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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