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The microRNA regulatory network in normal- and HTLV-1-transformed T cells.
- Source :
-
Advances in cancer research [Adv Cancer Res] 2012; Vol. 113, pp. 45-83. - Publication Year :
- 2012
-
Abstract
- Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes virology
Cell Line
Cell Transformation, Neoplastic genetics
Cell Transformation, Viral
Gene Expression Regulation, Neoplastic
HTLV-I Infections genetics
HTLV-I Infections pathology
Human T-lymphotropic virus 1 metabolism
Humans
Leukemia-Lymphoma, Adult T-Cell genetics
Leukemia-Lymphoma, Adult T-Cell pathology
Leukemia-Lymphoma, Adult T-Cell virology
RNA, Messenger metabolism
Transcriptome
CD4-Positive T-Lymphocytes pathology
Human T-lymphotropic virus 1 genetics
Human T-lymphotropic virus 1 pathogenicity
MicroRNAs genetics
MicroRNAs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2162-5557
- Volume :
- 113
- Database :
- MEDLINE
- Journal :
- Advances in cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 22429852
- Full Text :
- https://doi.org/10.1016/B978-0-12-394280-7.00002-6