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Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma.
- Source :
-
Blood [Blood] 2012 May 03; Vol. 119 (18), pp. 4215-23. Date of Electronic Publication: 2012 Mar 19. - Publication Year :
- 2012
-
Abstract
- The prognostic role of the transcription factor SOX11 in mantle cell lymphoma (MCL) is controversial. We investigated prognostic markers in a population-based cohort of 186 MCL cases. Seventeen patients (9%) did not require any therapy within the first 2 years after diagnosis and were retrospectively defined as having an indolent disease. As expected, indolent MCL had less frequent B symptoms and extensive nodal involvement and 88% of these cases expressed SOX11. In our cohort 13 cases (7.5%) lacked nuclear SOX11 at diagnosis. SOX11(-) MCL had a higher frequency of lymphocytosis, elevated level of lactate dehydrogenase (LDH), and p53 positivity. The overall survival in the whole cohort, excluding 37 patients receiving autologous stem cell transplantation, was 3.1 year and in patients with indolent or nonindolent disease, 5.9 and 2.8 years, respectively (P = .004). SOX11(-) cases had a shorter overall survival, compared with SOX11(+) cases, 1.5 and 3.2 years, respectively (P = .014). In multivariate analysis of overall survival, age > 65 (P = .001), Eastern Cooperative Oncology Group score ≥ 2 (P = .022), elevated LDH level (P = .001), and p53 expression (P = .001) remained significant, and SOX11 lost significance. We conclude that most indolent MCLs are SOX11(+) and that SOX11 cannot be used for predicting an indolent disease course.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor
Cell Nucleus chemistry
Cohort Studies
Combined Modality Therapy
Cyclin D1 analysis
Female
Hematopoietic Stem Cell Transplantation
Humans
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
L-Lactate Dehydrogenase analysis
Lymphoma, Mantle-Cell drug therapy
Lymphoma, Mantle-Cell mortality
Lymphoma, Mantle-Cell surgery
Male
Middle Aged
Prognosis
Transplantation, Autologous
Tumor Suppressor Protein p53 analysis
Lymphoma, Mantle-Cell chemistry
Neoplasm Proteins analysis
SOXC Transcription Factors analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 119
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 22431568
- Full Text :
- https://doi.org/10.1182/blood-2011-12-400580