Fragrance material review on dihydroisojasmone.

Authors :: Scognamiglio J
Jones L
Letizia CS
Api AM
Source :: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2012 Oct; Vol. 50 Suppl 3, pp. S600-3. Date of Electronic Publication: 2012 Mar 17.
Publication Year :: 2012
Abstract: A toxicologic and dermatologic review of dihydroisojasmone when used as a fragrance ingredient is presented. Dihydroisojasmone is a member of the fragrance structural group ketones cyclopentanones and cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for dihydroisojasmone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire ketones cyclopentanones and cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all ketones cyclopentanones and cyclopentenones in fragrances.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Cyclopentanes pharmacokinetics
Humans
Ketones pharmacokinetics
Rabbits
Rats
Toxicity Tests
Cyclopentanes toxicity
Ketones toxicity
Perfume
Skin drug effects

Language :: English
ISSN :: 1873-6351
Volume :: 50 Suppl 3
Database :: MEDLINE
Journal :: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Type :: Academic Journal
Accession number :: 22446812
Full Text :: https://doi.org/10.1016/j.fct.2012.03.029